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Phospho-JAK2/3 (Tyr966/939) Rabbit pAb

Anti-Phospho-JAK2/3 (Tyr966/939) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225093

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225093
Product Name:   Anti-Phospho-JAK2/3 (Tyr966/939) Rabbit pAb
Synonyms:   Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3)
UNIPROT ID:   O60674/P52333
Background:    Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
Immunogen:    Synthesized Phospho peptide derived from human JAK2/3.at AA range: T966
Applications:    WB,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 131 kDa; Observed MW: 120-130 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-JAK2/3 (Tyr966/939) in hela lysates using Phospho-JAK2/3 (Tyr966/939) antibody.

Western blot analysis of Phospho-JAK2/3 (Tyr966/939) in mouse liver, hela , mouse brain lysates using Phospho-JAK2/3 (Tyr966/939) antibody.
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