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Phospho-LRRK2 (Ser395) Rabbit pAb

Anti-Phospho-LRRK2 (Ser395) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225584

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225584
Product Name:   Anti-Phospho-LRRK2 (Ser395) Rabbit pAb
Synonyms:   AURA17; Dardarin antibody; ; Leucine rich repeat kinase 2; LRRK 2 antibody; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2
UNIPROT ID:   Q5S007
Background:    Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.
Immunogen:    A synthesized peptide derived from human Phospho-LRRK2 (S935)
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 286 kDa; Observed MW: 286 kDa
Isotype:    IgG
Purification:    Affinity Chromatography
Species Reactivity:    Human,Mouse
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Filamin A Phosphorylation in WTLRRK2 lysates treated LRRK2 using Phospho-LRRK2 (Ser395) antibody.
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