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Phospho-Rb2 p130 (Thr986) Rabbit mAb

Anti-Phospho-Rb2 p130 (Thr986) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N261714

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261714
Product Name:   Anti-Phospho-Rb2 p130 (Thr986) Rabbit Monoclonal Antibody
Synonyms:   Rb2; P130
UNIPROT ID:   Q08999
Background:    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R06-9B3
MW:    Calculated MW: 128 kDa; Observed MW: 128 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-Rb2 p130 (Thr986) in K562 lysates using Phospho-Rb2 p130 (Thr986) antibody.
          Publications