NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N225150 |
Product Name: Anti-Phospho-TAK1 (Thr187) Rabbit pAb |
Synonyms: MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1 |
UNIPROT ID: O43318 |
Background: Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B. |
Immunogen: The antiserum was produced against synthesized peptide derived from human MAP3K7 around the phosphorylation site of Thr187. AA range:161-210 |
Applications: WB,IHC-P,ELISA |
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000 |
Host Species: Rabbit |
Clonality: Rabbit Polyclonal |
Clone ID: – |
MW: Calculated MW: 67 kDa; Observed MW: 60 kDa |
Isotype: IgG |
Purification: Affinity Purified |
Species Reactivity: Human,Mouse,Rat |
Conjugation: Unconjugated |
Modification: Phosphorylated |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
Research Areas: Signal Transduction |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Western blot analysis of Phospho-TAK1 (Thr187) in 293T lysates using Phospho-TAK1 (Thr187) antibody. |