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PIM1 Rabbit mAb

Anti-PIM1 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263122

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263122
Product Name:   Anti-PIM1 Rabbit Monoclonal Antibody
Synonyms:   PIM1; Serine/threonine-protein kinase pim-1
UNIPROT ID:   P11309
Background:    Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.
Immunogen:    A synthetic peptide of human PIM1
Applications:    WB,IHC-P
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R08-8D5
MW:    Calculated MW: 36 kDa; Observed MW: 36 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human tonsil using PIM1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of PIM1 in Hela, A549, HL-60 lysates using PIM1 antibody.
          Publications