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PLEKHO1 Rabbit pAb

Anti-PLEKHO1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217290

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217290
Product Name:   Anti-PLEKHO1 Rabbit Polyclonal Antibody
Synonyms:   OC120; CKIP-1; RP11-458I7.3
UNIPROT ID:   Q53GL0 (Gene Accession – BC010149 )
Background:    Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by thePLEKHO1 gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF.
Immunogen:    Fusion protein of human PLEKHO1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 217290(PLEKHO1 Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 217290(Anti-PLEKHO1 Antibody) at dilution 1/40.
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