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PLOD2 Rabbit pAb

Anti-PLOD2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218914

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218914
Product Name:   Anti-PLOD2 Rabbit Polyclonal Antibody
Synonyms:   LH2; TLH; BRKS2
UNIPROT ID:   O00469 (Gene Accession – BC037169 )
Background:    The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen:    Fusion protein of human PLOD2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 150-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cancer, Cardiovascular, Metabolism
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 218914(PLOD2 Antibody) at a dilution of 1/100(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 218914(Anti-PLOD2 Antibody) at dilution 1/100.
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