Email: info@neweastbio.com   |  Call: 6109452007

PPM1A Rabbit pAb

Anti-PPM1A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217706

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217706
Product Name:   Anti-PPM1A Rabbit Polyclonal Antibody
Synonyms:   PP2CA; PP2Calpha; PP2C-ALPHA
UNIPROT ID:   P35813 (Gene Accession – BC026691 )
Background:    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Immunogen:    Fusion protein of human PPM1A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 217706(PPM1A Antibody) at a dilution of 1/120(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the fusion protein and then with 217706(Anti-PPM1A Antibody) at dilution 1/120.
          Publications