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PTCH1 Rabbit pAb

Anti-PTCH1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216755

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216755
Product Name:   Anti-PTCH1 Rabbit Polyclonal Antibody
Synonyms:   PTC; BCNS; PTC1; PTCH; NBCCS
UNIPROT ID:   Q13635 (Gene Accession – BC043542 )
Background:    This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly.
Immunogen:    Fusion protein of human PTCH1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer, Neuroscience, Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer tissue using 216755(PTCH1 Antibody) at a dilution of 1/70(Cytoplasm).

Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using 216755(Anti-PTCH1 Antibody) at a dilution of 1/70.

Gel: 6%SDS-PAGE, Lysate: 40 μg;
Lane: Mouse brain tissue lysate;
Primary antibody: 216755(PTCH1 Antibody) at dilution 1/1000;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 20 seconds
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