Email: info@neweastbio.com   |  Call: 6109452007

PTPRM Rabbit pAb

Anti-PTPRM Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220184

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220184
Product Name:   Anti-PTPRM Rabbit Polyclonal Antibody
Synonyms:   RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU
UNIPROT ID:   P28827 (Gene Accession – NP_002836 )
Background:    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
Immunogen:    Synthetic peptide of human PTPRM
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 220184(PTPRM Antibody) at a dilution of 1/80(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 220184(Anti-PTPRM Antibody) at dilution 1/80.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 220184(Anti-PTPRM Antibody) at a dilution of 1/80.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D261098(Anti-PTPRM Antibody) at dilution 1/80.
          Publications