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RAE1 Rabbit pAb

Anti-RAE1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217735

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217735
Product Name:   Anti-RAE1 Rabbit Polyclonal Antibody
Synonyms:   Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
UNIPROT ID:   P78406 (Gene Accession – BC106923 )
Background:    Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Immunogen:    Fusion protein of human RAE1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 200-400; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human ovarian cancer tissue using 217735(RAE1 Antibody) at a dilution of 1/220(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with the fusion protein and then with 217735(Anti-RAE1 Antibody) at dilution 1/220.
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