NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: S218164 | ||||
Product Name: Anti-RHEBL1 Rabbit Polyclonal Antibody | ||||
Synonyms: RHEBL1c | ||||
UNIPROT ID: Q8TAI7 (Gene Accession – BC027482 ) | ||||
Background: RhebL1 (ras homolog enriched in brain-like protein 1), also known as Rheb2 or GTPase RhebL1, is a 183 amino acid protein that belongs to the small GTPase superfamily and Rheb family. Localizing to the cell membrane as well as the cytoplasm, RhebL1 is ubiquitously expressed and is increased two-fold in many tumor cell lines. RhebL1 exhibits GTPase activity and may activate NF-kappa-B-mediated gene transcription. Regulating the activity of Rictor, RhebL1 also promotes signal transduction. RhebL1 exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 12q13.12 and mouse chromosome 15 F1. Human chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. | ||||
Immunogen: Fusion protein of human RHEBL1 | ||||
Applications: ELISA, IHC | ||||
Recommended Dilutions: IHC: 25-100; ELISA: 5000-10000 | ||||
Host Species: Rabbit | ||||
Clonality: Rabbit Polyclonal | ||||
Isotype: Immunogen-specific rabbit IgG | ||||
Purification: Antigen affinity purification | ||||
Species Reactivity: Human, Mouse, Rat | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||||
Research Areas: Epigenetics and Nuclear Signaling | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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