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SCIN Rabbit mAb

Anti-SCIN Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262874

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262874
Product Name:   Anti-SCIN Rabbit Monoclonal Antibody
Synonyms:   Scinderin
UNIPROT ID:   Q9Y6U3
Background:    Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).
Immunogen:    A synthetic peptide of human SCIN
Applications:    WB,IHC-P
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-6G2
MW:    Calculated MW: 80 kDa; Observed MW: 80 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using SCIN antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of SCIN in Hela lysates using SCIN antibody.
          Publications