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SCN11A Rabbit pAb

Anti-SCN11A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220193

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220193
Product Name:   Anti-SCN11A Rabbit Polyclonal Antibody
Synonyms:   NaN; SNS-2; NAV1.9; SCN12A
UNIPROT ID:   Q9UI33 (Gene Accession – NP_054858.2 )
Background:    Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
Immunogen:    Synthetic peptide of human SCN11A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 220193(SCN11A Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 220193(Anti-SCN11A Antibody) at dilution 1/50.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 220193(Anti-SCN11A Antibody) at a dilution of 1/50.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D261111(Anti-SCN11A Antibody) at dilution 1/50.
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