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SETD2 Rabbit pAb

Anti-SETD2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217058

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217058
Product Name:   Anti-SETD2 Rabbit Polyclonal Antibody
Synonyms:   HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
UNIPROT ID:   Q9BYW2 (Gene Accession – BC117162 )
Background:    Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Immunogen:    Fusion protein of human SETD2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217058(SETD2 Antibody) at a dilution of 1/30(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217058(Anti-SETD2 Antibody) at dilution 1/30.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 217058(Anti-SETD2 Antibody) at a dilution of 1/30.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with fusion protein and then with D221719(Anti-SETD2 Antibody) at dilution 1/30.
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