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SETD7 Rabbit pAb

Anti-SETD7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217505

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217505
Product Name:   Anti-SETD7 Rabbit Polyclonal Antibody
Synonyms:   KMT7; SET7; SET9; SET7/9
UNIPROT ID:   Q8WTS6 (Gene Accession – BC121055 )
Background:    The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.
Immunogen:    Fusion protein of human SETD7
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 217505(SETD7 Antibody) at a dilution of 1/20(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 217505(Anti-SETD7 Antibody) at dilution 1/20.
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