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SF3B3 Rabbit pAb

Anti-SF3B3 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219106

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219106
Product Name:   Anti-SF3B3 Rabbit Polyclonal Antibody
Synonyms:   RSE1; SAP130; SF3b130; STAF130
UNIPROT ID:   Q15393 (Gene Accession – BC000463 )
Background:    This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron’s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) comple,x and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Immunogen:    Fusion protein of human SF3B3
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 219106(SF3B3 Antibody) at a dilution of 1/70(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 219106(Anti-SF3B3 Antibody) at dilution 1/70.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 219106(Anti-SF3B3 Antibody) at a dilution of 1/70.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with fusion protein and then with D225849(Anti-SF3B3 Antibody) at dilution 1/70.
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