Email: info@neweastbio.com   |  Call: 6109452007

SLAMF7 Rabbit pAb

Anti-SLAMF7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216445

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216445
Product Name:   Anti-SLAMF7 Rabbit Polyclonal Antibody
Synonyms:   19A; CS1; CD319; CRACC
UNIPROT ID:   Q9NQ25 (Gene Accession – BC027867 )
Background:    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Immunogen:    Fusion protein of human SLAMF7
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer tissue using 216445(SLAMF7 Antibody) at a dilution of 1/30(Cell membrane).

Immunohistochemistry analysis of paraffin-embedded Human colorectal cancer tissue using 216445(Anti-SLAMF7 Antibody) at a dilution of 1/30.
          Publications