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SLC22A17 Rabbit pAb

Anti-SLC22A17 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220201

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220201
Product Name:   Anti-SLC22A17 Rabbit Polyclonal Antibody
Synonyms:   BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3
UNIPROT ID:   Q8WUG5 (Gene Accession – NP_065105.2 )
Background:    Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Immunogen:    Synthetic peptide of human SLC22A17
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 25-100;WB: 500-2000;ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 220201(SLC22A17 Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 220201(Anti-SLC22A17 Antibody) at dilution 1/30.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 220201(Anti-SLC22A17 Antibody) at a dilution of 1/30.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D261124(Anti-SLC22A17 Antibody) at dilution 1/30.

Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane: Human esophagus cancer tissue;
Primary antibody: 220201(SLC22A17 Antibody) at dilution 1/600;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 20 seconds
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