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SLFN5 Rabbit pAb

Anti-SLFN5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218647

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218647
Product Name:   Anti-SLFN5 Rabbit Polyclonal Antibody
Synonyms:   
UNIPROT ID:   Q08AF3 (Gene Accession – BC021238 )
Background:    Slfn5 (schlafen family member 5) is an 891 amino acid protein that exists as multiple alternatively spliced isoforms and is thought to play a role in hematopoeitic cell differentiation. The gene encoding Slfn5 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Immunogen:    Fusion protein of human SLFN5
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 218647(SLFN5 Antibody) at a dilution of 1/20(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 218647(Anti-SLFN5 Antibody) at dilution 1/20.
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