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SMAD7 Rabbit pAb

Anti-SMAD7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219995

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219995
Product Name:   Anti-SMAD7 Rabbit Polyclonal Antibody
Synonyms:   CRCS3; MADH7; MADH8
UNIPROT ID:   O15105 (Gene Accession – NP_001177750 )
Background:    The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Immunogen:    Synthetic peptide of human SMAD7
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human gastric cancer tissue using 219995(SMAD7 Antibody) at a dilution of 1/50(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with the synthetic peptide and then with 219995(Anti-SMAD7 Antibody) at dilution 1/50.
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