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STK3 Rabbit mAb

Anti-STK3 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262946

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262946
Product Name:   Anti-STK3 Rabbit Monoclonal Antibody
Synonyms:   STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2
UNIPROT ID:   Q13188
Background:    Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Immunogen:    A synthetic peptide of human STK3
Applications:    WB,IHC-P,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R04-8D3
MW:    Calculated MW: 56 kDa; Observed MW: 56 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat,Hamster
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using STK3 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of STK3/MST2 in 3T3, Raw264.7 lysates using STK3 antibody.

Western blot analysis of STK3/MST2 in CHO-K1, C6, Jurkat lysates using STK3/MST2 antibody.
          Publications