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TBL1XR1 Rabbit pAb

Anti-TBL1XR1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217883

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217883
Product Name:   Anti-TBL1XR1 Rabbit Polyclonal Antibody
Synonyms:   C21; DC42; IRA1; MRD41; TBLR1
UNIPROT ID:   Q9BZK7 (Gene Accession – BC113421 )
Background:    This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.
Immunogen:    Fusion protein of human TBL1XR1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 1000-5000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer, Metabolism
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 217883(TBL1XR1 Antibody) at a dilution of 1/75(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the fusion protein and then with 217883(Anti-TBL1XR1 Antibody) at dilution 1/75.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 217883(Anti-TBL1XR1 Antibody) at a dilution of 1/75.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D223295(Anti-TBL1XR1 Antibody) at dilution 1/75.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane: K562 cell lysate;
Primary antibody: 217883(TBL1XR1 Antibody) at dilution 1/1200;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 10 seconds
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