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TEAD2 Rabbit pAb

Anti-TEAD2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S212411

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S212411
Product Name:   Anti-TEAD2 Rabbit Polyclonal Antibody
Synonyms:   ETF; TEF4; TEF-4; TEAD-2
UNIPROT ID:   Q15562 (Gene Accession – BC007556 )
Background:    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC ‘enhansons’ (5′-GTGGAATGT-3′). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Immunogen:    Fusion protein of human TEAD2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 40-200; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human gastric cancer tissue using 212411(TEAD2 Antibody) at a dilution of 1/60(Nucleus).
          Publications