NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: S217894 | ||
Product Name: Anti-THAP4 Rabbit Polyclonal Antibody | ||
Synonyms: PP238; CGI-36 | ||
UNIPROT ID: Q8WY91 (Gene Accession – BC000247 ) | ||
Background: Human THAP4 is a 577 residue protein of unknown function that is proposed to bind DNA in a sequence specific manner similar to THAP1 and has been found to be upregulated in response to heat shock.THAP4 is expressed in a relatively uniform manner in a broad range of tissues and appears to be upregulated in lymphoma cells and highly expressed in heart cells13. The C-terminal domain of THAP4 (residues 415-577), designated here as cTHAP4, is evolutionarily conserved and is observed in all know THAP4 orthologues. Several single domain proteins lacking a THAP domain are found in plants and bacteria, and show significant levels of homology to cTHAP4. It appears that cTHAP4 belongs to a large class of proteins that have yet to be fully functionally characterized. | ||
Immunogen: Fusion protein of human THAP4 | ||
Applications: ELISA, IHC | ||
Recommended Dilutions: IHC: 25-100; ELISA: 2000-5000 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Polyclonal | ||
Isotype: Immunogen-specific rabbit IgG | ||
Purification: Antigen affinity purification | ||
Species Reactivity: Human, Mouse, Rat | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||
Research Areas: Epigenetics and Nuclear Signaling | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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