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TNFSF9 Rabbit pAb

Anti-TNFSF9 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222350

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222350
Product Name:   Anti-TNFSF9 Rabbit Polyclonal Antibody
Synonyms:   CD137L; TNLG5A; 4-1BB-L
UNIPROT ID:   P41273 (Gene Accession – NP_003802 )
Background:    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Immunogen:    Synthetic peptide of human TNFSF9
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-50; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 222350(TNFSF9 Antibody) at a dilution of 1/50(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 222350(Anti-TNFSF9 Antibody) at dilution 1/50.
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