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TNK2 Rabbit pAb

Anti-TNK2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219617

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219617
Product Name:   Anti-TNK2 Rabbit Polyclonal Antibody
Synonyms:   ACK, ACK1, ACK-1, p21cdc42Hs
UNIPROT ID:   Q07912 (Gene Accession – NP_005772 )
Background:    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Immunogen:    Synthetic peptide of human TNK2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 219617(TNK2 Antibody) at a dilution of 1/70(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 219617(Anti-TNK2 Antibody) at dilution 1/70.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 219617(Anti-TNK2 Antibody) at a dilution of 1/70.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D260024(Anti-TNK2 Antibody) at dilution 1/70.
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