Email: info@neweastbio.com   |  Call: 6109452007

TRIM56 Rabbit mAb

Anti-TRIM56 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263026

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263026
Product Name:   Anti-TRIM56 Rabbit Monoclonal Antibody
Synonyms:   RING finger protein 109; RNF109
UNIPROT ID:   Q9BRZ2
Background:    E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to ‘Lys-63’-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Immunogen:    A synthetic peptide of human TRIM56
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R02-8A3
MW:    Calculated MW: 81 kDa; Observed MW: 81 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of TRIM56(green) in Hela using TRIM56 antibody,and DAPI(blue)

Western blot analysis of TRIM56 in Hela lysates using TRIM56 antibody.
          Publications