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TRPM5 Rabbit pAb

Anti-TRPM5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S214011

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S214011
Product Name:   Anti-TRPM5 Rabbit Polyclonal Antibody
Synonyms:   MTR1; LTRPC5
UNIPROT ID:   Q9NZQ8 (Gene Accession – NP_055370 )
Background:    This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele.
Immunogen:    Synthetic peptide of human TRPM5
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 3000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 214011(TRPM5 Antibody) at a dilution of 1/60(Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 214011(Anti-TRPM5 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 214011(Anti-TRPM5 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D161187(Anti-TRPM5 Antibody) at dilution 1/60.

Gel: 10%SDS-PAGE, Lysate: 40 μg;
Lane: Mouse heart tissue;
Primary antibody: 214011(TRPM5 Antibody) at dilution 1/1200;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 20 seconds
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