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UGT1A4 Rabbit pAb

Anti-UGT1A4 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221082

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221082
Product Name:   Anti-UGT1A4 Rabbit Polyclonal Antibody
Synonyms:   UDPGT; UGT1D; UGT-1D; UGT1.4; HUG-BR2; UGT1-04; UGT1A4S; UDPGT 1-4
UNIPROT ID:   P22310 (Gene Accession – NP_009051 )
Background:    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
Immunogen:    Synthetic peptide of human UGT1A4
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Signal Transduction, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 221082(UGT1A4 Antibody) at a dilution of 1/30(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 221082(Anti-UGT1A4 Antibody) at dilution 1/30.
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