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UNC13B Rabbit pAb

Anti-UNC13B Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218323

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218323
Product Name:   Anti-UNC13B Rabbit Polyclonal Antibody
Synonyms:   UNC13; MUNC13; Unc13h2; munc13-2
UNIPROT ID:   O14795 (Gene Accession – BC111781 )
Background:    This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Immunogen:    Fusion protein of human UNC13B
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colorectal cancer tissue using 218323(UNC13B Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with the fusion protein and then with 218323(Anti-UNC13B Antibody) at dilution 1/40.
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