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WAPL Rabbit pAb

Anti-WAPL Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S214884

   Size:   100 μl

In Stock

            Product Description          
Cat.#:   S214884
Product Name:   Anti-WAPL Rabbit Polyclonal Antibody
Synonyms:   FOE; WAPAL; KIAA0261
UNIPROT ID:   Q7Z5K2 (Gene Accession – NP_055860 )
Background:    WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Immunogen:    Synthetic peptide of human WAPL
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 500-1000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 214884(WAPL Antibody) at a dilution of 1/35(Nucleus or Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 214884(Anti-WAPL Antibody) at dilution 1/35.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 214884(Anti-WAPL Antibody) at a dilution of 1/35.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D162487(Anti-WAPL Antibody) at dilution 1/35.
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