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YBX1 Rabbit pAb

Anti-YBX1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S220021

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S220021
Product Name:   Anti-YBX1 Rabbit Polyclonal Antibody
Synonyms:   YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1
UNIPROT ID:   P67809 (Gene Accession – NP_004550 )
Background:    This protein mediates pre-mRNA alternative splicing regulation. It binds to splice sites in pre-mRNA and regulates splice site selection and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It can regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ‘Lys-6’ and ‘Lys-7’. Binds to promoters that contain a Y-box (5′-CTGATTGGCCAA-3′), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro).
Immunogen:    Synthetic peptide of human YBX1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Stem Cells, Developmental Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 220021(YBX1 Antibody) at a dilution of 1/15(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 220021(Anti-YBX1 Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 220021(Anti-YBX1 Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D260790(Anti-YBX1 Antibody) at dilution 1/15.
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