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ZNF354A Rabbit pAb

Anti-ZNF354A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218247

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218247
Product Name:   Anti-ZNF354A Rabbit Polyclonal Antibody
Synonyms:   EZNF; HKL1; KID1; KID-1; TCF17; HEL104
UNIPROT ID:   O60765 (Gene Accession – BC047105 )
Background:    ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.
Immunogen:    Fusion protein of human ZNF354A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 218247(ZNF354A Antibody) at a dilution of 1/40(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the fusion protein and then with 218247(Anti-ZNF354A Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 218247(Anti-ZNF354A Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with fusion protein and then with D224025(Anti-ZNF354A Antibody) at dilution 1/40.
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