NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$239.00
BRCA2(352-643)
Cat. #: 26364-1 |
Gene Symbol: BRCA2, BRCC2, FAD1,FCD, BROVCA2, PNCA2 |
Description: Anti-BRCA2(352-643) Mouse Monoclonal Antibody |
Background: BRCA2 is a human tumor suppressor gene. Its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA. Mutations of BRCA2 can cause an increased risk of breast cancer. In addition to breast cancer in men and women, mutations in BRCA2 also lead to an increased risk of ovarian, Fallopian tube, prostate, and pancreatic cancers, as well as malignant melanoma. |
Immunogen: Purified BRCA2(352-643) protein, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes BRCA2(352-643) of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Purified His-tagged BRCA2(352-643) protein (lane1), His-tagged BRCA2 (1475-1748) protein(lane2), His-tagged BRCA2 (2213-2543) protein(lane3) and His-tagged BRCA2 (2793-3030) protein (lane4) were blotted with Anti-BRCA2(352-643) monoclonal antibody (Cat. #26364-1). Immunofluorescence: HEK293T cells was transfected with pCDNA3-GFP-BRCA2(352-643) plasmid, then fixed and stained with Anti-BRCA2(352-643) monoclonal antibody (Cat. #26364-1). |