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Canis lupus familiaris IL18BP Protein, hFc Tag

Recombinant Canis IL18BP protein with C-terminal human Fc tag
5/5

$739.00

Cat.#:  12123

   Size:   50 μg

In Stock

            Product Description          
Cat.#:     12123
Product Name:   Canis Lupus Familiaris IL18BP Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   IL18BP;IL18BPa;Tadekinig-alfa
Target:    IL18BP
UNIPROT ID:    F1PLB5
Description:    Recombinant Canis IL18BP protein with C-terminal human Fc tag
Background:     Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 43.7 kDa after removal of the signal peptide.The apparent molecular mass of dIL18BP-hFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    IL18BP(Thr31-Phe192) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Canis IL18BP Protein, hFc Tag on SDS-PAGE under reducing condition.
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