NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$689.00
Cat. #: 26203 | ||||
Size: 100 µL | ||||
Gene Symbol: CaSR | ||||
Description: CaSR VHH-FC (Recombinant monoclonal Nanobody, fused to Human Fc) | ||||
Background: Calcium-sensing receptor (CaSR) is a bioreceptor for various signaling molecules such as calcium ions (Ca2+). It is located on the surface of the cell membrane and belongs to the C-type G protein-coupled receptor family. CaSR mainly couples the intracellular Gq/11 class G protein signaling pathway, inducing the accumulation of phosphoinositide and endoplasmic reticulum Ca2+ release and other cellular physiological behaviors. CaSR can maintain calcium ion homeostasis in the body by controlling the secretion of parathyroid hormone and participates in various physiological processes such as bone metabolism. This product is a CaSR nanobody with high specificity and high affinity. It recognizes the extracellular structural region of CaSR and can be used in CaSR expression detection and immunoprecipitation experiments. It is a good CaSR detection tool. | ||||
Applications: Flow cytometry staining, immunostaining and Elisa, IP, Co-IP, IHC | ||||
Dilution: 1:500 | ||||
Molecular Weight: 90 kD | ||||
Species Reactivity: Human, Rat | ||||
Format: Liquid | ||||
Tag: His | ||||
Constituents: PBS, 40% Glycerol, 0.03% proclin300 | ||||
Species: Human, Rat | ||||
Storage Conditions: Store at 4℃, 6 months; -20℃, 2 years | ||||
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