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CD47 (DM212) Rabbit mAb

Anti-CD47 (DM212) Rabbit Monoclonal Antibody
5/5

$445.00

Cat.#:  28555

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28555
Product Name:   Anti-CD47(DM212) Rabbit Monoclonal Antibody
Synonyms:   CD47; MER6; IAP; OA3
Description:    Anti-CD47 antibody(DM212) Rabbit Monoclonal Antibody
Background:    Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3; Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets; and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA; binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion; enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit IgG
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human CD47
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Competition assay demonstrating DM212 blockade of SIRPα binding to Jurkat cell line.
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