$219.00
Cdc42 Polyclonal Antibody
| Cat. #: 21010 |
| Gene Symbol: CDC42 |
| Description: Anti-Cdc42 Rabbit Polyclonal Antibody |
| Background: Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). |
| Immunogen: A synthetic peptide from a unique region of Cdc42 |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA: 1:100-1:5000 WB: 1:100-1:2000 IHC: 1:50-100 |
| Concentration: 0.2 mg/ml |
| Host Species: Rabbit |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: IgG |
| Purity: Purified from serum |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Cdc42 antibody recognizes Cdc42 from vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: MEF whole-cell lysate was used for western blot with the polyclonal Anti-Cdc42 antibody (cat. #21010). |
| 1. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds Commun Biol. 2021 PMID: 34145387 |
| 2. The GABA B receptor mediates neuroprotection by coupling to G13 Sci Signal. 2021 PMID: 34665640 |
| 3. Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization FASEB J. 2019 PMID: 31682474 |
| 4. Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling PLoS Pathog. 2013 PMID: 23357873 |
| 5. Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells Cytokine. 2012 PMID: 22137120 |
| 6. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42 Am J Physiol Lung Cell Mol Physiol. 2011 PMID: 21036919 |
