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Human CMKLR1 Full Length Protein

Human CMKLR1 Full Length Protein-Synthetic Nanodisc
5/5

$4,400.00

Cat.#:  11107

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11107
Product Name:   Human CMKLR1 Full Length Protein
Size :    10 µg; 50 µg and 100 µg
Synonyms:   CHEMERINR; ChemR23; DEZ; RVER1
Target:    CMKLR1
UNIPROT ID:    Q99788
Description:    Human CMKLR1 Full Length Protein-Synthetic Nanodisc
Background:     Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Species/Host:    HEK293
Molecular Weight:    The human full length CMKLR1 protein has a MW of 42.3 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Protein Families:    Druggable Genome, GPCR, Transmembrane
Protein Pathways:    N/A

Figure 1. Elisa plates were pre-coated with Flag Tag CMKLR1-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with CMKLR1-Nanodisc is 2.107ng/ml.

Figure 2. Human CMKLR1-Nanodisc, Flag Tag on SDS-PAGE
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