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Human CXCR4 Full Length Protein

Human CXCR4 Full Length Protein-Synthetic Nanodisc


Cat.#:  11055

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11055
Product Name:   Human CXCR4 Full Length Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS
Target:    CXCR4
UNIPROT ID:    P61073
Description:    Human CXCR4 full length protein-synthetic nanodisc
Background:     A CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome.
Species/Host:    HEK293
Molecular Weight:    The human full length CXCR4 protein has a MW of 39.7 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure1. Elisa plates were pre-coated with Flag Tag CXCR4-Nanodisc (0.2 µg/per well). Serial diluted anti-CXCR4 monoclonal antibody (28101) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CXCR4 monoclonal antibody binding with CXCR4-Nanodisc is 2442ng/ml.

Figure2. Human CXCR4-Nanodisc, Flag Tag on SDS-PAGE