Subtotal:
$239.00
$4,400.00
| Cat.#: 11090 | ||
| Product Name: Human FZD7 Full Length Protein | ||
| Size : 10 µg; 50 µg and 100 µg | ||
| Synonyms: FzE3 | ||
| Target: FZD7 | ||
| UNIPROT ID: O75084 | ||
| Description: Human FZD7 Full Length Protein-Synthetic Nanodisc | ||
| Background: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The human full length FZD7 protein has a MW of 63.6 kDa | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
| Protein Families: Druggable Genome, Transmembrane | ||
| Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway | ||
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