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GDF15 (DMC474) IgG1 Chimeric mAb

Anti-GDF15 (DMC474) IgG1 Chimeric Monoclonal Antibody
5/5

$445.00

Cat.#:  28250

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28250
Product Name:   Anti-GDF15(DMC474) IgG1 Chimeric Monoclonal Antibody
Synonyms:   GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
Description:    Anti-GDF15 antibody(DMC474) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types; acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia; inflammation; acute injury and oxidative stress. [provided by RefSeq; Aug 2016]
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human GDF15
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-GDF15 (DMC474) on Expi293 cells transfected with human GDF15 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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