NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$445.00
Cat.#: 28543 |
Product Name: Anti-GM-CSF(DM200) Rabbit Monoclonal Antibody |
Synonyms: CSF; GMCSF |
Description: Anti-GM-CSF antibody(DM200) Rabbit Monoclonal Antibody |
Background: The protein encoded by this gene is a cytokine that controls the production; differentiation; and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31; which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4; 5; and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines; including the one produced by this gene; have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq; Aug 2020] |
Applications: ELISA; Flow Cyt |
Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 |
Host Species: Rabbit |
Isotype: Rabbit IgG |
Purification: Purified from cell culture supernatant by affinity chromatography |
Species Reactivity: Human GM-CSF |
Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. Flow cytometry analysis with Anti-GM-CSF (DM200) on Expi293 cells transfected with human GM-CSF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). |