NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$495.00
Gαq(Q209L)
Cat. #: 26328 |
Gene Symbol: GNAQ, CMC1, G-ALPHA-q, GAQ, SWS |
Description: Anti-GNAQ(Q209L) Mouse Monoclonal Antibody |
Background: GNAQ is a protein that in humans encoded by the GNAQ gene. The GNAQ protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospholipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. |
Immunogen: A synthetic peptide from the internal region of GNAQ which includes the mutation of Q209L, human origin. |
Applications: ELISA, IF, IHC |
Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
Concentration: 1 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes Gαq(Q209L) mutant, but not wild type Gαq of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Immunofluorescence: Western blot analysis of recombinant GNAQ(Q209L) and wild type proteins. Purified His-tagged GNAQ(Q209L) protein (lane 2) and corresponding wild type protein (lane 1) were blotted with anti-GNAQ(Q209L) monoclonal antibody (Cat. # 26328). |
Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQQ209L-driven melanoma Oncogenesis. 2016 PMID: 27348266 |