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Human ACVR1C Protein, hFc Tag

Recombinant Human ACVR1C Protein with C-terminal human Fc tag


Cat.#:  11892

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11892
Product Name:   Human ACVR1C Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   ACVRLK7;ALK7
Target:    ACVR1C
Description:    Recombinant Human ACVR1C Protein with C-terminal human Fc tag
Background:     ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR1C-hFc is approximately 35-70 kDa due to glycosylation.
Molecular Characterization:    ACVR1C(Leu22-Glu113) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human ACVR1C Protein, hFc Tag on SDS-PAGE under reducing condition.