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Human C5AR1 Protein, hFc Tag

Recombinant Human C5AR1 Protein with C-terminal human Fc tag


Cat.#:  11611

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11611
Product Name:   Human C5AR1 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   C5A;C5AR;C5R1;CD88
Target:    C5AR1
UNIPROT ID:    P21730
Description:    Recombinant Human C5AR1 Protein with C-terminal human Fc tag
Background:     Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 30.4 kDa after removal of the signal peptide.The apparent molecular mass of C5AR1-hFc is approximately 40-53 kDa due to glycosylation.
Molecular Characterization:    C5AR1(Met1-Asp37) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human C5AR1 Protein, hFc Tag on SDS-PAGE under reducing condition.