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Human CCR5 Protein, hFc Tag

Recombinant Human CCR5 Protein with C-terminal human Fc tag
5/5

$550.00

Cat.#:  11674

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11674
Product Name:   Human CCR5 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CC-CKR-5;CCCKR5;CCR-5;CD195;CKR-5;CKR5;CMKBR5;IDDM22
Target:    CCR5
UNIPROT ID:    P51681
Description:    Recombinant Human CCR5 Protein with C-terminal human Fc tag
Background:     This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 29.6 kDa after removal of the signal peptide.The apparent molecular mass of CCR5-hFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    CCR5(Met1-Ala30) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human CCR5 Protein, hFc Tag on SDS-PAGE under reducing condition.
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