Email: info@neweastbio.com   |  Call: 6109452007

Human CD4 Protein, hFc Tag

Recombinant human CD4 protein with C-terminal human Fc tag
5/5

$415.00

Cat.#:  11636

   Size:   100 μg

Under development

          Product Description          
Cat.#:     11636
Product Name:   Human CD4 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD4;D4mut;EU3
Target:    CD4
UNIPROT ID:    P01730
Description:    Recombinant human CD4 protein with C-terminal human Fc tag
Background:     This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 65.67 kDa after removal of the signal peptide.
Molecular Characterization:    CD4(Lys26-Trp390) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Publications