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Human DKK1 Protein, mFc Tag

Recombinant Human DKK1 Protein with C-terminal mouse Fc tag


Cat.#:  11903

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11903
Product Name:   Human DKK1 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   DKK-1;SK
Target:    DKK1
UNIPROT ID:    O94907
Description:    Recombinant Human DKK1 Protein with C-terminal mouse Fc tag
Background:     This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 52.0 kDa after removal of the signal peptide. The apparent molecular mass of DKK1-mFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    DKK1(Thr32-His266) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human DKK1 Protein, mFc Tag on SDS-PAGE under reducing condition.